Efflux-mediated antifungal drug resistance

RD Cannon, E Lam**, AR Holmes… - Clinical microbiology …, 2009 - Am Soc Microbiol
Fungi cause serious infections in the immunocompromised and debilitated, and the
incidence of invasive mycoses has increased significantly over the last 3 decades. Slow …

Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology

V Gogineni, MT Hamann - Biochimica et Biophysica Acta (BBA)-General …, 2018 - Elsevier
The oceans are a uniquely rich source of bioactive metabolites, of which sponges have
been shown to be among the most prolific producers of diverse bioactive secondary …

Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections

UR Abdelmohsen, S Balasubramanian… - The Lancet Infectious …, 2017 - thelancet.com
Antibiotics have revolutionised medicine in many aspects, and their discovery is considered
a turning point in human history. However, the most serious consequence of the use of …

Antimicrobial peptides–promising alternatives to conventional antibiotics

SA Baltzer, MH Brown - Microbial Physiology, 2011 - karger.com
Antimicrobial peptides (APs) have been described as evolutionary ancient weapons.
Produced by a wide variety of organisms as part of a non-specific immune response, these …

Targeting antimicrobial drug resistance with marine natural products

F Barbosa, E Pinto, A Kijjoa, M Pinto… - International journal of …, 2020 - Elsevier
The rise and spread of antimicrobial resistance represents one of the most pressing health
issues of today. Antimicrobial resistance in micro-organisms can arise due to a multiplicity of …

[HTML][HTML] Suppl 1: microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation

C Kourtesi, AR Ball, YY Huang, SM Jachak… - The open …, 2013 - ncbi.nlm.nih.gov
Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-
resistance among pathogenic microorganisms. The need to overcome these deficiencies …

Targeting efflux pumps to overcome antifungal drug resistance

AR Holmes, TS Cardno, JJ Strouse… - Future Medicinal …, 2016 - Taylor & Francis
Resistance to antifungal drugs is an increasingly significant clinical problem. The most
common antifungal resistance encountered is efflux pump-mediated resistance of Candida …

Marine cyclic peptides: Antimicrobial activity and synthetic strategies

R Ribeiro, E Pinto, C Fernandes, E Sousa - Marine Drugs, 2022 - mdpi.com
Oceans are a rich source of structurally unique bioactive compounds from the perspective of
potential therapeutic agents. Marine peptides are a particularly interesting group of …

Microbial efflux pump inhibition: tactics and strategies

GP Tegos, M Haynes, J Jacob Strouse… - Current …, 2011 - ingentaconnect.com
Traditional antimicrobials are increasingly suffering from the emergence of multidrug
resistance among pathogenic microorganisms. To overcome these deficiencies, a range of …

Microbial resistance: The role of efflux pump superfamilies and their respective substrates

ÍR Garcia, FA de Oliveira Garcia, PS Pereira… - Life Sciences, 2022 - Elsevier
The microorganism resistance to antibiotics has become one of the most worrying issues for
science due to the difficulties related to clinical treatment and the rapid spread of diseases …