Paradigm shifts in surgery arise when surgeons are empowered to perform surgery faster,
better and less expensively than current standards. Optical imaging that exploits invisible …

Nanomedicine is defined as “the application of nanotechnology to medicine, including the
use of nanometer-sized carrier materials for facilitating disease diagnosis, disease treatment …

Deposits of amyloid-β (Aβ) in the brains of rodents can be analysed by invasive intravital
microscopy on a submillimetre scale, or via whole-brain images from modalities lacking the …

Optical microscopy has been a fundamental tool of biological discovery for more than three
centuries, but its in vivo tissue imaging ability has been restricted by light scattering to …

A person suspected of having Alzheimer's disease (AD) is clinically diagnosed for the
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …

Optical imaging is a powerful modality in biological discovery. The mainstream of optical
interrogations, however, largely relies on microscopy, which imposes depth limitations on …

Fluorescence sampling of cellular function is widely used in all aspects of biology, allowing
the visualization of cellular and sub-cellular biological processes with spatial resolutions in …

Nanotechnology has brought a variety of new possibilities into biological discovery and
clinical practice. In particular, nano-scaled carriers have revolutionalized drug delivery …

Molecular imaging has emerged at the end of the last century as an interdisciplinary method
involving in vivo imaging and molecular biology aiming at identifying living biological …

The development of hybrid optical tomography methods to improve imaging performance
has been suggested over a decade ago and has been experimentally demonstrated in …