Proteolysis-targeting chimeras (PROTACs) and related molecules that induce targeted
protein degradation by the ubiquitin–proteasome system represent a new therapeutic …

Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are
a new modality of chemical tools and potential therapeutics to understand and treat human …

Abstract Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer
and inflammatory disease, and initiates potent innate immune responses through the …

The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …

Most human γδ T cells express Vγ2Vδ2 TCRs and play important roles in microbial and
tumor immunity. Vγ2Vδ2 T cells are stimulated by self-and foreign prenyl pyrophosphate …

The SPRY domain is a protein interaction module found in 77 murine and∼ 100 human
proteins, and is implicated in important biological pathways, including those that regulate …

19F-NMR has proved to be a valuable tool in fragment-based drug discovery. Its
applications include screening libraries of fluorinated fragments, assessing competition …

Histone H3 Lys-4 methylation is predominantly catalyzed by a family of methyltransferases
whose enzymatic activity depends on their interaction with a three-subunit complex …

Abstract Vγ2Vδ2 T cells play important roles in human immunity to pathogens and in cancer
immunotherapy by responding to isoprenoid metabolites, such as (E)-4-hydroxy-3-methyl …