Type 1 interferons as a potential treatment against COVID-19
Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a
clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the …
clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the …
Shared and distinct functions of type I and type III interferons
Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …
including induction by viral infection, activation of shared signaling pathways, and …
The lung microbiome regulates brain autoimmunity
L Hosang, RC Canals, FJ van der Flier, J Hollensteiner… - Nature, 2022 - nature.com
Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated
autoimmune disease of the central nervous system. In addition, the lung serves as a niche …
autoimmune disease of the central nervous system. In addition, the lung serves as a niche …
Immunomodulation—a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system
M Strzelec, J Detka, P Mieszczak… - Frontiers in …, 2023 - frontiersin.org
In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …
pharmacological, and medical techniques which can be implemented in the functional …
Epstein–Barr virus in multiple sclerosis: theory and emerging immunotherapies
New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere
of excitement in the MS community. B cells are now known to play a major role in disease …
of excitement in the MS community. B cells are now known to play a major role in disease …
Therapeutic advances in multiple sclerosis
Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system that
causes significant disability and healthcare burden. The treatment of MS has evolved over …
causes significant disability and healthcare burden. The treatment of MS has evolved over …
Thinking outside the box: non-canonical targets in multiple sclerosis
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
Mitochondrial DNA damage triggers spread of Parkinson's disease-like pathology
E Tresse, J Marturia-Navarro, WQG Sew… - Molecular …, 2023 - nature.com
In the field of neurodegenerative diseases, especially sporadic Parkinson's disease (sPD)
with dementia (sPDD), the question of how the disease starts and spreads in the brain …
with dementia (sPDD), the question of how the disease starts and spreads in the brain …
The science and medicine of human immunology
BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …
detection and neutralization of pathogens. History is replete with the devastating effects of …
Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements
A Pandey, AN Nikam, AB Shreya, SP Mutalik… - Life sciences, 2020 - Elsevier
The present pandemic of SARS-CoV-2 has been a tough task for the whole world to deal
with. With the absence of specific drugs or vaccines against SARS-CoV-2, the situation is …
with. With the absence of specific drugs or vaccines against SARS-CoV-2, the situation is …