Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials

M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - Elsevier
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

Microbiota-derived metabolites as drivers of gut–brain communication

H Ahmed, Q Leyrolle, V Koistinen, O Kärkkäinen… - Gut …, 2022 - Taylor & Francis
Alterations in the gut microbiota composition have been associated with a range of
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …

DrugBank 6.0: the DrugBank knowledgebase for 2024

C Knox, M Wilson, CM Klinger, M Franklin… - Nucleic acids …, 2024 - academic.oup.com
First released in 2006, DrugBank (https://go. drugbank. com) has grown to become the 'gold
standard'knowledge resource for drug, drug–target and related pharmaceutical information …

Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases

Y Chen, T Lu, U Pettersson-Kymmer, ID Stewart… - Nature …, 2023 - nature.com
Metabolic processes can influence disease risk and provide therapeutic targets. By
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …

Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine

A Heinken, J Hertel, G Acharya, DA Ravcheev… - Nature …, 2023 - nature.com
The human microbiome influences the efficacy and safety of a wide variety of commonly
prescribed drugs. Designing precision medicine approaches that incorporate microbial …

Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

L Chen, DV Zhernakova, A Kurilshikov… - Nature medicine, 2022 - nature.com
The levels of the thousands of metabolites in the human plasma metabolome are strongly
influenced by an individual's genetics and the composition of their diet and gut microbiome …

HMDB 5.0: the human metabolome database for 2022

DS Wishart, AC Guo, E Oler, F Wang… - Nucleic acids …, 2022 - academic.oup.com
Abstract The Human Metabolome Database or HMDB (https://hmdb. ca) has been providing
comprehensive reference information about human metabolites and their associated …

[HTML][HTML] Paternal microbiome perturbations impact offspring fitness

A Argaw-Denboba, TSB Schmidt, M Di Giacomo… - Nature, 2024 - nature.com
The gut microbiota operates at the interface of host–environment interactions to influence
human homoeostasis and metabolic networks,,–. Environmental factors that unbalance gut …

Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

S Alseekh, A Aharoni, Y Brotman, K Contrepois… - Nature …, 2021 - nature.com
Mass spectrometry-based metabolomics approaches can enable detection and
quantification of many thousands of metabolite features simultaneously. However …

Short chain fatty acids: Microbial metabolites for gut-brain axis signalling

KJ O'Riordan, MK Collins, GM Moloney… - Molecular and Cellular …, 2022 - Elsevier
The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to
prominence in recent years. Understanding the relationship between the gut microbiota, the …