The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

The nature of dorsal root reflexes (DRRs) and their possible role in peripheral inflammation
and the consequent hyperalgesia are reviewed. The history of DRRs and the relationship of …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

1. The aim of this review is to consider the relative roles of inhibitory and excitatory amino
acid receptor-mediated events in the processes leading to pain transmission in the spinal …

In this paper we review the current neurophysiological models of touch-evoked pain and
present a new proposal that addresses the mechanisms of allodynia. The new model is …

Abnormal pain-related behaviour that accompanies peripheral nerve injury may be the
result of altered spinal neuronal function. The long-term loss of inhibitory function by GABA …

Whole-cell patch-clamp recordings were made from substantia gelatinosa (SG) neurons in
thick adult rat transverse spinal cord slices with attached dorsal roots to study changes in …

The role of dorsal root reflexes (DRRs) in acute cutaneous neurogenic inflammation induced
by intradermal injection of capsaicin (CAP) was examined in anesthetized rats. Changes in …

A lack of inhibition, particularly that mediated by gamma-amino butyric acid (GABA), the
main inhibitory transmitter of the central nervous system (CNS), is responsible for many pain …

Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in
the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies …