Designing antibodies as therapeutics

PJ Carter, A Rajpal - Cell, 2022 - cell.com
Antibody therapeutics are a large and rapidly expanding drug class providing major health
benefits. We provide a snapshot of current antibody therapeutics including their formats …

Oral drug delivery platforms for biomedical applications

J Ouyang, Z Zhang, B Deng, J Liu, L Wang, H Liu… - Materials Today, 2023 - Elsevier
Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …

The future of drug delivery

J Gao, JM Karp, R Langer, N Joshi - Chemistry of Materials, 2023 - ACS Publications
Drug delivery technologies have been proven to improve treatment outcomes in many ways,
including enhancing therapeutic efficacy, reducing toxicity, increasing patient compliance …

Wireless soft millirobots for climbing three-dimensional surfaces in confined spaces

Y Wu, X Dong, J Kim, C Wang, M Sitti - Science Advances, 2022 - science.org
Wireless soft-bodied robots at the millimeter scale allow traversing very confined
unstructured terrains with minimal invasion and safely interacting with the surrounding …

Acid-resistant and physiological pH-responsive DNA hydrogel composed of A-motif and i-motif toward oral insulin delivery

Y Hu, S Gao, H Lu, JY Ying - Journal of the American Chemical …, 2022 - ACS Publications
An acid-resistant DNA hydrogel that is stable in an extremely acidic environment with pH as
low as 1.2 has not been reported before, largely due to the instability of DNA-hybridized …

Gastrointestinal tract drug delivery using algae motors embedded in a degradable capsule

F Zhang, Z Li, Y Duan, A Abbas, R Mundaca-Uribe… - Science robotics, 2022 - science.org
The use of micromotors for active drug delivery via oral administration has recently gained
considerable interest. However, efficient motor-assisted delivery into the gastrointestinal (GI) …

Theranostic nanoparticles with disease-specific administration strategies

P Zhang, Y Li, W Tang, J Zhao, L **g, KJ McHugh - Nano Today, 2022 - Elsevier
Recent advances in the synthesis of nanomaterials with diagnostic and therapeutic
capabilities have been rapidly resha** the landscape of precision medicine. Impressive …

A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy

B Hou, L Yi, D Hu, Z Luo, D Gao, C Li, B **ng… - Nature Biomedical …, 2023 - nature.com
Monitoring X-ray radiation in the gastrointestinal tract can enhance the precision of
radiotherapy in patients with gastrointestinal cancer. Here we report the design and …

Recent advances in oral and transdermal protein delivery systems

Y Yang, R Zhou, Y Wang, Y Zhang, J Yu… - Angewandte …, 2023 - Wiley Online Library
Protein and peptide drugs are predominantly administered by injection to achieve high
bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug …

Preclinical proof of principle for orally delivered Th17 antagonist miniproteins

S Berger, F Seeger, TY Yu, M Aydin, H Yang… - Cell, 2024 - cell.com
Summary Interleukin (IL)-23 and IL-17 are well-validated therapeutic targets in
autoinflammatory diseases. Antibodies targeting IL-23 and IL-17 have shown clinical …