Designing antibodies as therapeutics
Antibody therapeutics are a large and rapidly expanding drug class providing major health
benefits. We provide a snapshot of current antibody therapeutics including their formats …
benefits. We provide a snapshot of current antibody therapeutics including their formats …
Oral drug delivery platforms for biomedical applications
Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …
The future of drug delivery
Drug delivery technologies have been proven to improve treatment outcomes in many ways,
including enhancing therapeutic efficacy, reducing toxicity, increasing patient compliance …
including enhancing therapeutic efficacy, reducing toxicity, increasing patient compliance …
Wireless soft millirobots for climbing three-dimensional surfaces in confined spaces
Wireless soft-bodied robots at the millimeter scale allow traversing very confined
unstructured terrains with minimal invasion and safely interacting with the surrounding …
unstructured terrains with minimal invasion and safely interacting with the surrounding …
Acid-resistant and physiological pH-responsive DNA hydrogel composed of A-motif and i-motif toward oral insulin delivery
An acid-resistant DNA hydrogel that is stable in an extremely acidic environment with pH as
low as 1.2 has not been reported before, largely due to the instability of DNA-hybridized …
low as 1.2 has not been reported before, largely due to the instability of DNA-hybridized …
Gastrointestinal tract drug delivery using algae motors embedded in a degradable capsule
The use of micromotors for active drug delivery via oral administration has recently gained
considerable interest. However, efficient motor-assisted delivery into the gastrointestinal (GI) …
considerable interest. However, efficient motor-assisted delivery into the gastrointestinal (GI) …
Theranostic nanoparticles with disease-specific administration strategies
Recent advances in the synthesis of nanomaterials with diagnostic and therapeutic
capabilities have been rapidly resha** the landscape of precision medicine. Impressive …
capabilities have been rapidly resha** the landscape of precision medicine. Impressive …
A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy
Monitoring X-ray radiation in the gastrointestinal tract can enhance the precision of
radiotherapy in patients with gastrointestinal cancer. Here we report the design and …
radiotherapy in patients with gastrointestinal cancer. Here we report the design and …
Recent advances in oral and transdermal protein delivery systems
Protein and peptide drugs are predominantly administered by injection to achieve high
bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug …
bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug …
Preclinical proof of principle for orally delivered Th17 antagonist miniproteins
S Berger, F Seeger, TY Yu, M Aydin, H Yang… - Cell, 2024 - cell.com
Summary Interleukin (IL)-23 and IL-17 are well-validated therapeutic targets in
autoinflammatory diseases. Antibodies targeting IL-23 and IL-17 have shown clinical …
autoinflammatory diseases. Antibodies targeting IL-23 and IL-17 have shown clinical …