Membrane electroporation and electropermeabilization: mechanisms and models

T Kotnik, L Rems, M Tarek… - Annual review of …, 2019‏ - annualreviews.org
Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient
increase in their plasma membrane permeability, allowing transmembrane transport of …

Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019‏ - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Electroporation-based applications in biotechnology

T Kotnik, W Frey, M Sack, SH Meglič, M Peterka… - Trends in …, 2015‏ - cell.com
Electroporation is already an established technique in several areas of medicine, but many
of its biotechnological applications have only started to emerge; we review here some of the …

Impact of plastic particles on the horizontal transfer of antibiotic resistance genes to bacterium: dependent on particle sizes and antibiotic resistance gene vector …

X Hu, MG Waigi, B Yang, Y Gao - Environmental science & …, 2022‏ - ACS Publications
Plastic particles impact the propagation of antibiotic resistance genes (ARGs) in
environmental media, and their perturbation on the horizontal gene transfer (HGT) of ARGs …

Molecular machines open cell membranes

V García-López, F Chen, LG Nilewski, G Duret… - Nature, 2017‏ - nature.com
Beyond the more common chemical delivery strategies, several physical techniques are
used to open the lipid bilayers of cellular membranes. These include using electric and …

Clinical potential of electroporation for gene therapy and DNA vaccine delivery

L Lambricht, A Lopes, S Kos, G Sersa… - Expert opinion on …, 2016‏ - Taylor & Francis
Introduction: Electroporation allows efficient delivery of DNA into cells and tissues, thereby
improving the expression of therapeutic or immunogenic proteins that are encoded by …

Arginine “magic”: Guanidinium like-charge ion pairing from aqueous salts to cell penetrating peptides

M Vazdar, J Heyda, PE Mason, G Tesei… - Accounts of chemical …, 2018‏ - ACS Publications
It is a textbook knowledge that charges of the same polarity repel each other. For two
monovalent ions in the gas phase at a close contact this repulsive interaction amounts to …

Advances in molecular understanding of α-helical membrane-active peptides

I Kabelka, R Vacha - Accounts of Chemical Research, 2021‏ - ACS Publications
Conspectus Biological membranes separate the interior of cells or cellular compartments
from their outer environments. This barrier function of membranes can be disrupted by …

Pore formation in lipid membrane I: Continuous reversible trajectory from intact bilayer through hydrophobic defect to transversal pore

SA Akimov, PE Volynsky, TR Galimzyanov, PI Kuzmin… - Scientific reports, 2017‏ - nature.com
Lipid membranes serve as effective barriers allowing cells to maintain internal composition
differing from that of extracellular medium. Membrane permeation, both natural and artificial …

Pulsed electric fields for cardiac ablation and beyond: a state-of-the-art review

E Maor, A Sugrue, C Witt, VR Vaidya, CV DeSimone… - Heart rhythm, 2019‏ - Elsevier
Irreversible electroporation (IRE) occurs when a strong, pulsed electric field (PEF) causes
permeabilization of the cell membrane, leading to cellular homeostasis disruption and cell …