Studies have shown that the presence of tumor infiltrating lymphocytes (TILs) in Triple
Negative Breast Cancer (TNBC) is associated with better prognosis. However, the molecular …

Defining the number and abundance of different cell types in tissues is important for
understanding disease mechanisms as well as for diagnostic and prognostic purposes …

There is a critical unmet need for safe and efficacious neoadjuvant treatment for cisplatin-
ineligible patients with muscle-invasive bladder cancer. Here we launched a phase 1b study …

Background The tumor microenvironment (TME) is increasingly appreciated as an important
determinant of cancer outcome, including in multiple myeloma (MM). However, most …

Skeletal muscle plays an integral role in coordinating physiological homeostasis, where
signaling to other tissues via myokines allows for coordination of complex processes. Here …

Immunochemotherapy has been the mainstay of treatment for newly diagnosed diffuse large
B-cell lymphoma (ndDLBCL) yet is inadequate for many patients. In this work, we perform …

Tissue immune cells have long been recognized as important regulators for the
maintenance of balance in the body system. Quantification of the abundance of different …

Tumor immune microenvironmental alterations occur early in multiple myeloma (MM)
development. In this study, we aim to systematically characterize the tumor immune …

A robust prognostic and biological classification for newly diagnosed follicular lymphoma
(FL) using molecular profiling remains challenging. FL tumors from patients treated in the …

RNA sequencing (RNA-seq) is widely used to identify differentially expressed genes (DEGs)
and reveal biological mechanisms underlying complex biological processes. RNA-seq is …