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[HTML][HTML] Targeting Wnt signaling for the treatment of gastric cancer
S Koushyar, AG Powell, E Vincan… - International Journal of …, 2020 - mdpi.com
The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic
development and maintaining adult tissue homeostasis. Wnt signaling controls several …
development and maintaining adult tissue homeostasis. Wnt signaling controls several …
[HTML][HTML] Nobiletin and xanthohumol sensitize colorectal cancer stem cells to standard chemotherapy
Simple Summary Colorectal cancer stem cells (CR-CSCs) play a pivotal role in the therapy
resistance and relapse of CRC patients. Herein we demonstrate that new treatment …
resistance and relapse of CRC patients. Herein we demonstrate that new treatment …
Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines
W Wang, P Liu, M Lavrijsen, S Li, R Zhang, S Li… - Scientific Reports, 2021 - nature.com
AXIN1 mutations are observed in 8–10% of hepatocellular carcinomas (HCCs) and
originally were considered to support tumor growth by aberrantly enhancing β-catenin …
originally were considered to support tumor growth by aberrantly enhancing β-catenin …
[HTML][HTML] A small-molecule tankyrase inhibitor reduces glioma stem cell proliferation and sphere formation
Evidence suggests that the growth and therapeutic resistance of glioblastoma (GBM) may be
enabled by a population of glioma stem cells (GSCs) that are regulated by typical stem cell …
enabled by a population of glioma stem cells (GSCs) that are regulated by typical stem cell …
Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
L Mygland, SA Brinch, MF Strand, PA Olsen… - Iscience, 2021 - cell.com
Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor
agents in selected tumor cell lines and mouse models. Here, we characterized the response …
agents in selected tumor cell lines and mouse models. Here, we characterized the response …