As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of
the critical and complex roles played by p53 is progressing rapidly, new findings continue to …

Abnormalities of the p53 tumour suppressor gene are among the most frequent molecular
events in human and animal neoplasia. Moreover, p53 is one of the most studied proteins in …

EBV was the first human virus to be directly implicated in carcinogenesis. It infects> 90% of
the world's population. Although most humans coexist with the virus without serious …

From its modest beginnings in 1979, as a transformation-associated protein, to the
discoveries that p53 plays a key role in tumour suppression and in the cellular response to …

BACKGROUND & AIMS: Epstein–Barr virus (EBV) has been causally associated with
cancer; some gastric carcinomas have a monoclonal EBV genome in every cancer cell …

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus associated with the
development of both lymphoid and epithelial tumours. As a common virus infection, EBV …

Chronic active hepatitis caused by infection with hepatitis B virus, a DNA virus, is a major
risk factor for human hepatocellular carcinoma. Since the oncogenicity of several DNA …

A subset of patients who have undergone coronary angioplasty develop restenosis, a vessel
renarrowing characterized by excessive proliferation of smooth muscle cells (SMCs). Of 60 …

Apoptosis is the process whereby individual cells of multicellular organisms undergo
systematic self-destruction in response to a wide variety of stimuli. Apoptosis is a genetically …

Interactions between the host and viruses during the course of their co-evolution have not
only shaped cellular function and the immune system, but also the counter measures …