CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular
signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed …

CD 38 is a multifunctional cell surface protein that has receptor as well as enzyme functions.
The protein is generally expressed at low levels on various hematological and solid tissues …

Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of nicotinamide adenine
dinucleotide (NAD+) known to promote cellular NAD+ production and counteract age …

The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of
enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most …

PD1 blockade therapy, harnessing the cytotoxic potential of CD8+ T cells, has yielded
clinical success in treating malignancies. However, its efficacy is often limited due to the …

Deregulation of apoptosis, the physiological form of cell death, is closely associated with
immunological diseases and cancer. Apoptosis is activated either by death receptor-driven …

ABSTRACT A previously unrecognized passive transport for pyridine dinucleotides has
been described recently in the plasmamembrane of several mammalian cells. Despite …

Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP)
are two Ca2+ messengers derived from NAD and NADP, respectively. Although NAADP is a …

The metabolism of NAD has emerged as a key regulator of cellular and organismal
homeostasis. Being a major component of both bioenergetic and signaling pathways, the …

Over the past decades, the pyridine nucleotides have been established as important
molecules in signaling pathways, besides their well known function in energy transduction …