Challenges in the diagnosis of Parkinson's disease

E Tolosa, A Garrido, SW Scholz, W Poewe - The Lancet Neurology, 2021 - thelancet.com
Parkinson's disease is the second most common neurodegenerative disease and its
prevalence has been projected to double over the next 30 years. An accurate diagnosis of …

Parkinson disease

R Balestrino, AHV Schapira - European journal of neurology, 2020 - Wiley Online Library
Parkinson disease (PD) is the most common neurodegenerative movement disorder. In
Europe, prevalence and incidence rates for PD are estimated at approximately 108–257/100 …

Aerobic exercise alters brain function and structure in Parkinson's disease: a randomized controlled trial

ME Johansson, IGM Cameron… - Annals of …, 2022 - Wiley Online Library
Objective Randomized clinical trials have shown that aerobic exercise attenuates motor
symptom progression in Parkinson's disease, but the underlying neural mechanisms are …

Gait impairments in Parkinson's disease

A Mirelman, P Bonato, R Camicioli, TD Ellis… - The Lancet …, 2019 - thelancet.com
Gait impairments are among the most common and disabling symptoms of Parkinson's
disease. Nonetheless, gait is not routinely assessed quantitatively but is described in …

Evolution of prodromal Parkinson's disease and dementia with Lewy bodies: a prospective study

SM Fereshtehnejad, C Yao, A Pelletier, JY Montplaisir… - Brain, 2019 - academic.oup.com
Parkinson's disease has a long prodromal stage with various subclinical motor and non-
motor manifestations; however, their evolution in the years before Parkinson's disease is …

Clinical criteria for subty** Parkinson's disease: biomarkers and longitudinal progression

SM Fereshtehnejad, Y Zeighami, A Dagher… - Brain, 2017 - academic.oup.com
Parkinson's disease varies widely in clinical manifestations, course of progression and
biomarker profiles from person to person. Identification of distinct Parkinson's disease …

Gut microbiota are related to Parkinson's disease and clinical phenotype

F Scheperjans, V Aho, PAB Pereira… - Movement …, 2015 - Wiley Online Library
In the course of Parkinson's disease (PD), the enteric nervous system (ENS) and
parasympathetic nerves are amongst the structures earliest and most frequently affected by …

Long-term effect of regular physical activity and exercise habits in patients with early Parkinson disease

K Tsukita, H Sakamaki-Tsukita, R Takahashi - Neurology, 2022 - AAN Enterprises
Background and Objectives Owing to the lack of long-term observations or comprehensive
adjustment for confounding factors, reliable conclusions regarding long-term effects of …

Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson's disease

H Nishiwaki, M Ito, T Hamaguchi, T Maeda… - npj Parkinson's …, 2022 - nature.com
To elucidate the relevance of gut dysbiosis in Parkinson's disease (PD) in disease
progression, we made random forest models to predict the progression of PD in two years by …

Parkinson disease subtypes

MA Thenganatt, J Jankovic - JAMA neurology, 2014 - jamanetwork.com
Importance It is increasingly evident that Parkinson disease (PD) is not a single entity but
rather a heterogeneous neurodegenerative disorder. Objective To evaluate available …