The human mitochondrial genome is extremely small compared with the nuclear genome,
and mitochondrial genetics presents unique clinical and experimental challenges. Despite …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Reproduction is required for the survival of all mammalian species, and thousands of
essential'sex'genes are conserved through evolution. Basic research helps to define these …

BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

Mitochondria are found in all eukaryotic cells and contain their own genome (mitochondrial
DNA or mtDNA). Unlike the nuclear genome, which is derived from both the egg and sperm …

Mitochondria play a vital role in the metabolism of energy-containing compounds in the
oocyte cytoplasm to provide adenosine trisphosphate for fertilization and preimplantation …

Decreasing oocyte competence with maternal aging is a major factor in human infertility. To
investigate the age-dependent molecular changes in a mouse model, we compared the …

Tractable and accurate disease models are essential for understanding disease
pathogenesis and for develo** new therapeutics. As stem cells are capable of self …