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The sirtuin family in health and disease
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …
misfolded protein accumulations may be found in the diverse signaling pathways of the …
Intranasal delivery of BACE1 siRNA and rapamycin by dual targets modified nanoparticles for Alzheimer's disease therapy
X Yang, W Yang, X **a, T Lei, Z Yang, W Jia, Y Zhou… - Small, 2022 - Wiley Online Library
Abstract Alzheimer's disease (AD), as a progressive and irreversible brain disorder, remains
the most universal neurodegenerative disease. No effective therapeutic methods are …
the most universal neurodegenerative disease. No effective therapeutic methods are …
[HTML][HTML] Hallmarks of aging: an autophagic perspective
Autophagy is a major protein turnover pathway by which cellular components are delivered
into the lysosomes for degradation and recycling. This intracellular process is able to …
into the lysosomes for degradation and recycling. This intracellular process is able to …
Role of lysosomes in physiological activities, diseases, and therapy
Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …
Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model
K Freitag, N Sterczyk, S Wendlinger… - Journal of …, 2022 - Springer
Background Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial
cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer's …
cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer's …
The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer's disease
H Du, X Meng, Y Yao, J Xu - Frontiers in Endocrinology, 2022 - frontiersin.org
Since type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease (AD) and both
have the same pathogenesis (eg, insulin resistance), drugs used to treat T2DM have been …
have the same pathogenesis (eg, insulin resistance), drugs used to treat T2DM have been …
Evolving and expanding the roles of mitophagy as a homeostatic and pathogenic process
ÅB Gustafsson, GW Dorn - Physiological reviews, 2019 - journals.physiology.org
The central functions fulfilled by mitochondria as both energy generators essential for tissue
homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight …
homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight …
[HTML][HTML] Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy
Abstract Alzheimer's disease (AD), characterized by the accumulation of protein aggregates
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …