Cellular function of phosphoinositide 3-kinases: implications for development, immunity, homeostasis, and cancer
R Katso, K Okkenhaug, K Ahmadi… - Annual review of cell …, 2001 - annualreviews.org
▪ Abstract The phosphoinositide 3-kinase (PI3K) family of enzymes is recruited upon growth
factor receptor activation and produces 3′ phosphoinositide lipids. The lipid products of …
factor receptor activation and produces 3′ phosphoinositide lipids. The lipid products of …
Hydrogen peroxide as second messenger in lymphocyte activation
M Reth - Nature immunology, 2002 - nature.com
Oxidants such as H2O2 are connected to lymphocyte activation, but the molecular
mechanisms behind this phenomenon are less clear. Here, I review data suggesting that by …
mechanisms behind this phenomenon are less clear. Here, I review data suggesting that by …
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
The activation-induced cytidine deaminase (AID) gene, specifically expressed in germinal
center B cells in mice, is a member of the cytidine deaminase family. We herein report …
center B cells in mice, is a member of the cytidine deaminase family. We herein report …
Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling
The development of B cells is dependent on the sequential DNA rearrangement of
immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a …
immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a …
B cell antigen receptor signaling 101
JM Dal Porto, SB Gauld, KT Merrell, D Mills… - Molecular …, 2004 - Elsevier
All cells continually survey their environment and make decisions based on cues
encountered. This requires specific receptors that detect such cues, then transduce signals …
encountered. This requires specific receptors that detect such cues, then transduce signals …
Humanin peptide suppresses apoptosis by interfering with Bax activation
B Guo, D Zhai, E Cabezas, K Welsh, S Nouraini… - Nature, 2003 - nature.com
Bax (Bcl2-associated X protein) is an apoptosis-inducing protein that participates in cell
death during normal development and in various diseases. Bax resides in an inactive state …
death during normal development and in various diseases. Bax resides in an inactive state …
Origins and functions of B-1 cells with notes on the role of CD5
R Berland, HH Wortis - Annual review of immunology, 2002 - annualreviews.org
Whether B-1a (CD5+) cells are a distinct lineage derived from committed fetal/neonatal
precursors or arise from follicular B-2 cells in response to BCR ligation and other, unknown …
precursors or arise from follicular B-2 cells in response to BCR ligation and other, unknown …
Immune contexture, immunoscore, and malignant cell molecular subgroups for prognostic and theranostic classifications of cancers
The outcome of tumors results from genetic and epigenetic modifications of the transformed
cells and also from the interactions of the malignant cells with their tumor microenvironment …
cells and also from the interactions of the malignant cells with their tumor microenvironment …
BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway
By diversifying antibody biological effector functions, class switch DNA recombination has a
central role in the maturation of the antibody response. Here we show that BCR-signalling …
central role in the maturation of the antibody response. Here we show that BCR-signalling …
Marginal zone B cells
S Pillai, A Cariappa, ST Moran - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Our views regarding the origins and functions of splenic marginal zone B cells
have changed considerably over the past few years. Perspectives regarding the …
have changed considerably over the past few years. Perspectives regarding the …