Until recently, it has been impossible to approach learning with the techniques of cell
biology. During the past several years, elementary forms of learning have been analyzed in …

Protein phosphorylation represents an approach, sometimes the only approach available, to
study the molecular basis for a wide variety of neurophysiological phenomena. The injection …

Synapsin I (protein I) is a neuron-specific phosphoprotein, which is a substrate for cAMP-
dependent and Ca/calmodulin-dependent protein kinases. In two accompanying studies (De …

The vasodilator-stimulated phosphoprotein (VASP) is a major substrate for cAMP-dependent-
(cAK) and cGMP-dependent protein kinase (cGK) in human platelets and other …

Voltage-gated L-type Ca2+ channels mediate Ca2+ entry into cells in response to
membrane depolarization. Ca2+ entry through the cardiac Ca2+ channel determines the …

The development and functional analysis of a monoclonal antibody (16C2) are reported; the
antibody recognizes vasodilator-stimulated phosphoprotein (VASP; an established substrate …

Regulation of epithelial chloride flux, which is defective in patients with cystic fibrosis, may
be mediated by phosphorylation of the cystic fibrosis transmembrane conductance regulator …

Neurons process and transmit information in the form of electrical signals. Their electrical
excitability is due to the presence of voltage-sensitive ion channels in the neuronal plasma …

It has been difficult to establish whether cyclic AMP-mediated protein phosphorylation in
nerve cells plays a specific role in synaptic transmission. This difficulty can be overcome in …

Synapsin I is a neuron-specific phosphoprotein localized to the cytoplasmic surface of
synaptic vesicles1, 2. This phosphoprotein is a major substrate for cyclic AMP-dependent …