Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

The purpose of these guidelines is to assist physicians in recommending, performing,
interpreting and reporting the results of FDG PET/CT for oncological imaging of adult …

Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle
coupled to the electron transport chain. Most energy in mammals is produced via TCA …

Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate
contributes to energy metabolism in living tumors. We previously reported that human non …

Non-small cell lung cancer (NSCLC) is heterogeneous in the genetic and environmental
parameters that influence cell metabolism in culture. Here, we assessed the impact of these …

Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …

Purpose Image quality of positron emission tomography (PET) is limited by various physical
degradation factors. Our study aims to perform PET image denoising by utilizing prior …

PET imaging involves radiotracer injections, raising concerns about the risk of radiation
exposure. To minimize the potential risk, one way is to reduce the injected tracer. However …

Tumors exhibit genomic and phenotypic heterogeneity, which has prognostic significance
and may influence response to therapy. Imaging can quantify the spatial variation in …

The processes of cellular growth regulation and cellular metabolism are closely interrelated.
The c-Myc oncogene is a “master regulator” which controls many aspects of both of these …