Obesity and its comorbidities, including type 2 diabetes mellitus, cardiovascular disease,
heart failure and non-alcoholic liver disease are a major health and economic burden with …

The microtubule network of cardiac muscle cells has unique architectural and biophysical
features to accommodate the demands of the working heart. Advances in live-cell imaging …

Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …

Passive mechanical tissue properties are major determinants of myocardial contraction and
relaxation and, thus, shape cardiac function. Tightly regulated, dynamically adapting …

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome associated
with increased myocardial stiffness and cardiac filling abnormalities. Prior studies implicated …

Among the variety of post-translational modifications to which microtubules are subjected,
the detyrosination/re-tyrosination cycle is specific to tubulin. It is conserved by evolution and …

Aging is a complex feature and involves loss of multiple functions and nonreversible
phenotypes. However, several studies suggest it is possible to protect against aging and …

Passive stiffness of the heart is determined largely by extracellular matrix and titin, which
functions as a molecular spring within sarcomeres. Titin stiffening is associated with the …

Cardiomyopathies are a heterogeneous collection of diseases that have in common primary
functional and structural abnormalities of the heart muscle, often genetically determined. The …

Myocardial stiffness is an intrinsic property of the myocardium that influences both diastolic
and systolic cardiac function. Myocardial stiffness represents the resistance of this tissue to …