Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring
clonal advantage as the initial event. However, despite pervasive somatic mutations and …

Extrachromosomal DNA (ecDNA) has recently been recognized as a major contributor to
cancer pathogenesis that is identified in most cancer types and is associated with poor …

Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours
and their resistance to treatment, and is associated with poor outcomes for patients with …

Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving
aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of …

Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural
and numerical chromosomal abnormalities during cell division, which contributes to tumour …

Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It
has been observed in most cancer types and is associated with worse patient outcome. The …

Abstract High-order three-dimensional (3D) interactions between more than two genomic
loci are common in human chromatin, but their role in gene regulation is unclear. Previous …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their
origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here …

Human cancer cell lines have long served as tools for cancer research and drug discovery,
but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we …