Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer.
Interestingly, lactate closely links them together. However, lactate has long been recognized …

During an inflammatory process, shift in the cellular metabolism associated with an increase
in extracellular acidification are well-known features. This pH drop in the inflamed tissue is …

Gastrointestinal cancer is currently one of the main causes of cancer death, with a large
number of cases and a wide range of lesioned sites. A high fat diet, as a public health …

The development of sequencing technology has expanded our knowledge of the human
gastric microbiome, which is now known to play a critical role in the maintenance of …

Intestinal metaplasia (IM) is the inevitable precancerous stage to develop intestinal-type
gastric cancer (GC). Deoxycholic acid (DCA) is the main bile acid (BA) component of …

The discovery of Helicobacter pylori in 1982 drew to an end the stomach being considered
as a sterile organ. Later, the progress in molecular methods, especially Next Generation …

Helicobacter pylori infection is still the main risk factor for the development of gastric cancer
(GC). We explore the scientific evidence for the role of the gastric microbiome beyond …

Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene
transcription via lactylation of histones and non-histone proteins, ie, a novel posttranslational …

Cancer cells tend to utilize aerobic glycolysis to generate energy and metabolites; the end
product of aerobic glycolysis is lactate, which promotes lysine lactylation (Kla). Kla is a newly …