There are numerous proteases of pathogenic organisms that are currently targeted for
therapeutic intervention along with many that are seen as potential drug targets. This review …

Exosomes are small vesicles of endocytic origin, which are released into the extracellular
environment and mediate a variety of physiological and pathological conditions. Here we …

The hygiene hypothesis states that improved hygiene and the resulting disappearance of
once endemic diseases is at the origin of the enormous increase in immune related …

Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is the
most used, fast, and reproducible method to confirm large-scale gene expression data. The …

Background Sparganosis is an infection with a larval Diphyllobothriidea tapeworm. From a
rare cerebral case presented at a clinic in the UK, DNA was recovered from a biopsy sample …

Schistosoma haematobium affects more than 100 million people throughout Africa and is the
causative agent of urogenital schistosomiasis. The parasite is strongly associated with …

The trypsin-like proteases (TLPs) play widespread and diverse roles, in a host of
physiological and pathological processes including clot dissolution, extracellular matrix …

Background Serine proteases are important virulence factors for many pathogens. Recently,
we discovered a group of trypsin-like serine proteases with domain organization unique to …

Background Blood flukes of the genus Schistosoma cause schistosomiasis, a parasitic
disease that infects over 240 million people worldwide, and for which there is a need to …

Schistosomiasis is one of a number of chronic helminth diseases of poverty that severely
impact personal and societal well-being and productivity. Peptidases (proteases) are vital to …