A comprehensive guide to MEGA-PRESS for GABA measurement

AL Peek, TJ Rebbeck, AM Leaver, SL Foster… - Analytical …, 2023 - Elsevier
The aim of this guideline is to provide a series of evidence-based recommendations that
allow those new to using MEGA-PRESS to produce high-quality data for the measurement of …

Theoretical description of modern 1H in Vivo magnetic resonance spectroscopic pulse sequences

K Landheer, RF Schulte, MS Treacy… - Journal of Magnetic …, 2020 - Wiley Online Library
This article reviews the most commonly used modern sequences designed to confront the
two major challenges of in vivo magnetic resonance spectroscopy (MRS): spatial …

Thalamic and prefrontal GABA concentrations but not GABAA receptor densities are altered in high-functioning adults with autism spectrum disorder

LK Fung, RE Flores, M Gu, KL Sun, D James… - Molecular …, 2021 - nature.com
The gamma aminobutyric acid (GABA) neurotransmission system has been implicated in
autism spectrum disorder (ASD). Molecular neuroimaging studies incorporating …

Higher levels of pro-inflammatory cytokines are associated with higher levels of glutamate in the anterior cingulate cortex in depressed adolescents

TC Ho, GI Teresi, JR Segarra, A Ojha… - Frontiers in …, 2021 - frontiersin.org
Animal models of stress and related conditions, including depression, have shown that
elevated peripheral levels of inflammatory cytokines have downstream consequences on …

MEGA‐PRESS of GABA+: influences of acquisition parameters

DK Deelchand, M Marjańska, PG Henry… - NMR in …, 2021 - Wiley Online Library
γ‐aminobutyric acid (GABA) was the first molecule that was edited with MEGA‐PRESS.
GABA edited spectroscopy is challenged by limited selectivity of editing pulses. Coediting of …

Simultaneous editing of GABA and GSH with Hadamard‐encoded MR spectroscopic imaging

KL Chan, G Oeltzschner, MG Saleh… - Magnetic resonance …, 2019 - Wiley Online Library
Purpose To evaluate the feasibility of simultaneous MR spectroscopic imaging (MRSI) of
gamma‐aminobutyric acid (GABA) and glutathione (GSH) in the human brain using …

[HTML][HTML] Neurometabolite differences in Autism as assessed with Magnetic Resonance Spectroscopy: A systematic review and meta-analysis

AR Thomson, D Pasanta, T Arichi, NA Puts - Neuroscience & Biobehavioral …, 2024 - Elsevier
Abstract 1 H-Magnetic Resonance Spectroscopy (MRS) is a non-invasive technique that can
be used to quantify the concentrations of metabolites in the brain in vivo. MRS findings in the …

[HTML][HTML] 1H-MRS neurometabolites and associations with neurite microstructures and cognitive functions in amnestic mild cognitive impairment

E Gozdas, L Hinkley, H Fingerhut, L Dacorro, M Gu… - NeuroImage: Clinical, 2022 - Elsevier
Alzheimer's disease (AD) pathogenesis is associated with alterations in neurometabolites
and cortical microstructure. However, our understanding of alterations in neurochemicals in …

Simultaneous optimization of crusher and phase cycling schemes for magnetic resonance spectroscopy: an extension of dephasing optimization through coherence …

K Landheer, C Juchem - Magnetic Resonance in Medicine, 2020 - Wiley Online Library
Purpose To extend the dephasing optimization through coherence order pathway selection
(DOTCOPS) algorithm, originally designed solely for gradient crusher schemes, to include …

The relationship between resting cerebral blood flow, neurometabolites, cardio-respiratory fitness and aging-related cognitive decline

V Krishnamurthy, I Paredes Spir, KM Mammino… - Frontiers in …, 2022 - frontiersin.org
Older adults typically experience a decline in cognitive function, but improvements in
physical health and lifestyle can be neuroprotective across the human lifespan. The primary …