Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
Ribosomal protein S6: a potential therapeutic target against cancer?
Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …
Monosomes actively translate synaptic mRNAs in neuronal processes
INTRODUCTION RNA sequencing and in situ hybridization have revealed the presence of
an unexpectedly high number of RNA species in neuronal dendrites and axons, and many …
an unexpectedly high number of RNA species in neuronal dendrites and axons, and many …
Cerebellar dopamine D2 receptors regulate social behaviors
The cerebellum, a primary brain structure involved in the control of sensorimotor tasks, also
contributes to higher cognitive functions including reward, emotion and social interaction …
contributes to higher cognitive functions including reward, emotion and social interaction …
Ribosomal protein S6 phosphorylation: four decades of research
O Meyuhas - International review of cell and molecular biology, 2015 - Elsevier
The phosphorylation of ribosomal protein S6 (rpS6) has been described for the first time
about four decades ago. Since then, numerous studies have shown that this modification …
about four decades ago. Since then, numerous studies have shown that this modification …
Ribosomal protein S6 phosphorylation in the nervous system: from regulation to function
Since the discovery of the phosphorylation of the 40S ribosomal protein S6 (rpS6) about four
decades ago, much effort has been made to uncover the molecular mechanisms underlying …
decades ago, much effort has been made to uncover the molecular mechanisms underlying …
The tail of the striatum: from anatomy to connectivity and function
E Valjent, G Gangarossa - Trends in neurosciences, 2021 - cell.com
The dorsal striatum, the largest subcortical structure of the basal ganglia, is critical in
controlling motor, procedural, and reinforcement-based behaviors. Although in mammals the …
controlling motor, procedural, and reinforcement-based behaviors. Although in mammals the …
The Arabidopsis TOR kinase specifically regulates the expression of nuclear genes coding for plastidic ribosomal proteins and the phosphorylation of the cytosolic …
T Dobrenel, E Mancera-Martinez, C Forzani… - Frontiers in plant …, 2016 - frontiersin.org
Protein translation is an energy consuming process that has to be fine-tuned at both the cell
and organism levels to match the availability of resources. The target of rapamycin kinase …
and organism levels to match the availability of resources. The target of rapamycin kinase …
Dopamine D2 receptors gate generalization of conditioned threat responses through mTORC1 signaling in the extended amygdala
Overgeneralization of conditioned threat responses is a robust clinical marker of anxiety
disorders. In overgeneralization, responses that are appropriate to threat-predicting cues are …
disorders. In overgeneralization, responses that are appropriate to threat-predicting cues are …
Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum
Action control is a key brain function determining the survival of animals in their
environment. In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal …
environment. In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal …