Regenerative medicine is extensively interested in develo** cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

The signaling networks that drive the aging process, associated functional deterioration, and
pathologies has captured the scientific community's attention for decades. While many …

Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-
faceted senescence-associated secretory phenotype (SASP). Loss of mitochondrial function …

Several cancer interventions induce DNA damage and promote senescence in cancer and
nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors …

Cellular senescence is a state of stable proliferation arrest of cells. The senescence pathway
has many beneficial effects and is seen to be activated in damaged/stressed cells, as well as …

Cellular senescence is an important mechanism for preventing the proliferation of potential
cancer cells. Recently, however, it has become apparent that this process entails more than …

Oncogenic ras can transform most immortal rodent cells to a tumorigenic state. However,
transformation of primary cells by ras requires either a cooperating oncogene or the …

Cells continually experience stress and damage from exogenous and endogenous sources,
and their responses range from complete recovery to cell death. Proliferating cells can …

The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms.
Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and …

Inflammation underlies most age-related diseases, including cancer, but the etiology is
poorly understood. One proposed factor is the presence of senescent cells, which increase …