Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome is a
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …

The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …

The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However,
whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is …

The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Gasdermins were recently identified as the mediators of pyroptosis—inflammatory cell death
triggered by cytosolic sensing of invasive infection and danger signals. Upon activation …

NLRP3 inflammasome activation is a highly regulated process for controlling secretion of the
potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection …

Abstract NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …