The sulfur biochemistry of the thiol group endows cysteines with a number of highly
specialized and unique features that enable them to serve a variety of different functions in …

Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …

Bacterial secondary metabolites are a major source of antibiotics and other bioactive
compounds. In microbial communities, these molecules can mediate interspecies …

BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

An essential prerequisite for any systems-level understanding of cellular functions is to
correctly uncover and annotate all functional interactions among proteins in the cell. Toward …

Infections caused by antibiotic-resistant bacteria are a rising public health threat and make
the identification of new antibiotics a priority. From a cell-based screen for bactericidal …

Summary Low-molecular-weight (LMW) thiols are small-molecule antioxidants required for
the maintenance of intracellular redox homeostasis. However, many host-associated …

Deinococcus bacteria are famous for their extreme resistance to ionising radiation and other
DNA damage-and oxidative stress-generating agents. More than a hundred genes have …

Cysteine is notable among the universal, proteinogenic amino acids for its facile redox
chemistry. Cysteine thiolates are readily modified by reactive oxygen species (ROS) …

Among the biologically required first row, late d-block metals from Mn II to Zn II, the catalytic
and structural reach of Zn II ensures that this essential micronutrient touches nearly every …