An increasing demand for directed assembly of biomaterials has inspired the development
of bioprinting, which facilitates the assembling of both cellular and acellular inks into well …

Small molecules that modulate stem cell fate and function offer significant opportunities that
will allow the full realization of the therapeutic potential of stem cells. Rational design and …

The segmental organization of the vertebral column is established early in embryogenesis,
when pairs of somites are rhythmically produced by the presomitic mesoderm (PSM). The …

Human embryonic stem cells (hESCs) are derived from the inner cell mass of the blastocyst.
Despite sharing the common property of pluripotency, hESCs are notably distinct from …

Cell banking, disease modeling, and cell therapy applications have placed increasing
demands on hiPSC technology. Specifically, the high-throughput derivation of footprint-free …

Despite the great potential of stem cells for basic research and clinical applications,
obstacles–such as their scarce availability and difficulty in controlling their fate–need to be …

Epigenetic mechanisms are known to define cell-type identity and function. Hence,
reprogramming of one cell type into another essentially requires a rewiring of the underlying …

BACKGROUND: The diversity of cell types and tissue types that originate throughout
development derives from the differentiation potential of embryonic stem cells and somatic …

The defining features of embryonic stem cells (ESCs) are their self-renewing and pluripotent
capacities. Indeed, the ability to give rise into all cell types within the organism not only …

Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic,
as well as germ cells. The epiblast of the early mammalian embryo is the founder population …