The ATP-driven chaperone valosin-containing protein (VCP)/p97 governs critical steps in
ubiquitin-dependent protein quality control and intracellular signalling pathways. It …

Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …

VCP (also known as p97 or Cdc48p in yeast) is an AAA+ ATPase regulating endoplasmic
reticulum–associated degradation. After high-throughput screening, we developed …

We describe a procedure for designing proteins with backbones produced by varying the
parameters in the Crick coiled coil–generating equations. Combinatorial design calculations …

Resolution of replication forks during termination of DNA replication is essential for accurate
duplication of eukaryotic genomes. Here we present evidence consistent with the idea that …

Introduction Chromosome replication is initiated by a universal mechanism in eukaryotic
cells. This mechanism entails the assembly and activation at replication origins of the DNA …

Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to
malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment …

Abstract Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient
DNA replication and transcription. TOP1 is also a major driver of endogenous genome …

The accumulation of the human tumor suppressor 53BP1 at DNA damage sites requires the
ubiquitin ligases RNF8 and RNF168. As 53BP1 recognizes dimethylated Lys20 in histone …

Targeting tumor-infiltrating regulatory T (TI-Treg) cells is a potential strategy for cancer
therapy. The ATPase p97 in complex with cofactors (such as Npl4) has been investigated as …