Using singlet oxygen to synthesize natural products and drugs
This Review describes singlet oxygen (1O2) in the organic synthesis of targets on possible
1O2 biosynthetic routes. The visible-light sensitized production of 1O2 is not only useful for …
1O2 biosynthetic routes. The visible-light sensitized production of 1O2 is not only useful for …
Biologically active γ-lactams: synthesis and natural sources
The γ-lactam moiety is present in a large number of natural and non-natural biologically
active compounds. The range of biological activities covered by these compounds is very …
active compounds. The range of biological activities covered by these compounds is very …
Photoredox-catalyzed diastereoselective dearomative prenylation and reverse-prenylation of electron-deficient indole derivatives
X Chang, F Zhang, S Zhu, Z Yang, X Feng… - Nature …, 2023 - nature.com
Prenylated and reverse-prenylated indolines are privileged scaffolds in numerous naturally
occurring indole alkaloids with a broad spectrum of important biological properties …
occurring indole alkaloids with a broad spectrum of important biological properties …
Quinoline-based antimalarial hybrid compounds
S Vandekerckhove, M D'hooghe - Bioorganic & medicinal chemistry, 2015 - Elsevier
Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …
Enantioselective Michael/Cyclization Reaction Sequence: Scaffold‐Inspired Synthesis of Spirooxindoles with Multiple Stereocenters
A‐spiro‐ing: The title reaction of α‐isothiocyanato imides and methyleneindolinones has
been realized for the first time using 1 as the catalyst. This newly developed synthetic …
been realized for the first time using 1 as the catalyst. This newly developed synthetic …
Asymmetric Alkenyl C−H Functionalization by CpxRhIII forms 2H‐Pyrrol‐2‐ones through [4+1]‐Annulation of Acryl Amides and Allenes
SG Wang, Y Liu, N Cramer - Angewandte Chemie, 2019 - Wiley Online Library
An efficient CpxRhIII‐catalyzed enantioselective alkenyl C− H functionalization/[4+ 1]
annulation of acryl amides and allenes is reported. The described transformation provides …
annulation of acryl amides and allenes is reported. The described transformation provides …
Expanding the range of 'druggable'targets with natural product-based libraries: an academic perspective
Existing drugs address a relatively narrow range of biological targets. As a result, libraries of
drug-like molecules have proven ineffective against a variety of challenging targets, such as …
drug-like molecules have proven ineffective against a variety of challenging targets, such as …
Recent progress towards transition metal-catalyzed synthesis of γ-lactams
The occurrence of the γ-lactam unit in the framework of various biologically active
compounds has greatly contributed to the design and development of new synthetic …
compounds has greatly contributed to the design and development of new synthetic …
Catalytic access to carbocation intermediates via nitrenoid transfer leading to allylic lactams
Carbocation intermediacy is postulated in numerous organic transformations and provides
the foundation for retrosynthetic logics in chemical synthesis. Although a number of catalytic …
the foundation for retrosynthetic logics in chemical synthesis. Although a number of catalytic …
Antimicrobial strategies effective against infectious bacterial biofilms
M Simoes - Current medicinal chemistry, 2011 - ingentaconnect.com
Bacteria are able to adapt to undesirable changes in nutrient availability, environmental
conditions and presence of antimicrobial products, as well as to immunological defenses …
conditions and presence of antimicrobial products, as well as to immunological defenses …