The macromolecular enzyme complex prothrombinase serves an indispensable role in
blood coagulation as it catalyzes the conversion of prothrombin to thrombin, a key regulatory …

Background Prothrombin, protein C, and factors VII, IX, and X are vitamin K (VK)‐dependent
coagulation proteins that play an important role in the initiation, amplification, and …

Background The residue at the site of activation of protein C is Arg in all species except the
ray-finned fish, where it is Trp. This feature raises the question of whether thrombin is the …

Protein C is a natural anticoagulant activated by thrombin in a reaction accelerated by the
cofactor thrombomodulin. The zymogen to protease conversion of protein C involves …

Background Current assays that monitor thrombin generation in plasma rely on fluorogenic
substrates to follow the kinetics of zymogen activation, which may be complicated by …

Classical hemophilia results from a defect of the intrinsic tenase complex, the main factor X
(FX) activator. Binding of factor VIIa to tissue factor triggers coagulation, but little …

The conversion of zymogen Factor X (FX) to an active protease involves the removal of a 52‐
residue long activation peptide (AP). Through site‐directed mutagenesis, we investigate the …

Abstract Coagulation factors VII (FVII), IX (FIX), X (FX), and protein C share the same domain
organization but display very different plasma half-lives. It is plausible that the half-life is …

The venom of the Australian snake Pseudonaja textilis comprises powerful prothrombin
activators consisting of factor X (v-ptFX)-and factor V-like proteins. While all vertebrate liver …

1 Khorana AA, Francis CW, Culakova E, Fisher RI, Kuderer NM, Lyman GH.
Thromboembolism in hospitalized neutropenic cancer patients. J Clin Oncol 2006; 24: 484 …