Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Highlights•Microfluidics is transforming traditional techniques in biotechnology.•Multi-step
experiments are automated on single device in parallel reactors.•Millions of parallel …

The widespread use of antibiotics has placed bacterial pathogens under intense pressure to
evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis …

Plasmids are key vehicles of horizontal gene transfer (HGT), mobilizing antibiotic resistance,
virulence, and other traits among bacterial populations. The environmental and genetic …

Various toxic compounds disrupt bacterial physiology. While bacteria harbor defense
mechanisms to mitigate the toxicity, these mechanisms are often coupled to the …

The spread of antibiotic resistance is a global challenge that is fueled by evolution and
ecological processes. Therefore, the design of new sustainable therapy should take account …

Extracorporeal membrane oxygenation (ECMO) is an emerging treatment modality
associated with a high frequency of antibiotic use. However, several covariables emerge …

Antimicrobial prescription in critically ill patients represents a complex challenge due to the
difficult balance between infection treatment and toxicity prevention. Underexposure to …

Much is known about the effects of antibiotics on isolated bacterial species, but their
influence on polybacterial communities is less understood. Here, we study the joint …

Bacterial memory refers to the phenomenon in which past experiences influence current
behaviors in response to changing environments. It serves as a crucial process that enables …