The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
[HTML][HTML] Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs
The native tissues are complex structures consisting of different cell types, extracellular
matrix materials, and biomolecules. Traditional tissue engineering strategies have not been …
matrix materials, and biomolecules. Traditional tissue engineering strategies have not been …
A reference map of the human binary protein interactome
Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships …
understanding of the interactome networks that mediate genotype–phenotype relationships …
Critical assessment of protein intrinsic disorder prediction
Intrinsically disordered proteins, defying the traditional protein structure–function paradigm,
are a challenge to study experimentally. Because a large part of our knowledge rests on …
are a challenge to study experimentally. Because a large part of our knowledge rests on …
A deep-learning framework for multi-level peptide–protein interaction prediction
Peptide-protein interactions are involved in various fundamental cellular functions and their
identification is crucial for designing efficacious peptide therapeutics. Recently, a number of …
identification is crucial for designing efficacious peptide therapeutics. Recently, a number of …
MobiDB: intrinsically disordered proteins in 2021
The MobiDB database (URL: https://mobidb. org/) provides predictions and annotations for
intrinsically disordered proteins. Here, we report recent developments implemented in …
intrinsically disordered proteins. Here, we report recent developments implemented in …
ELM—the eukaryotic linear motif resource in 2020
M Kumar, M Gouw, S Michael… - Nucleic acids …, 2020 - academic.oup.com
Studies on the DNA-binding properties of transcription factors are important in searching for
the downstream genes regulated by these factors. In the present study, we report on the …
the downstream genes regulated by these factors. In the present study, we report on the …
Phase separation as a missing mechanism for interpretation of disease mutations
It is unclear how disease mutations impact intrinsically disordered protein regions (IDRs),
which lack a stable folded structure. These mutations, while prevalent in disease, are …
which lack a stable folded structure. These mutations, while prevalent in disease, are …
Intrinsically disordered proteins: an overview
Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …
structure under physiological conditions; instead, they adopt multiple interconverting …
Diverse molecular mechanisms underlying pathogenic protein mutations: beyond the loss-of-function paradigm
L Backwell, JA Marsh - Annual review of genomics and human …, 2022 - annualreviews.org
Most known disease-causing mutations occur in protein-coding regions of DNA. While some
of these involve a loss of protein function (eg, through premature stop codons or missense …
of these involve a loss of protein function (eg, through premature stop codons or missense …