Current strategies and findings in clinically relevant post-translational modification-specific proteomics

O Pagel, S Loroch, A Sickmann… - Expert review of …, 2015 - Taylor & Francis
Mass spectrometry-based proteomics has considerably extended our knowledge about the
occurrence and dynamics of protein post-translational modifications (PTMs). So far …

Recent advances in mass spectrometry (MS)-based glycoproteomics in complex biological samples

Z Chen, J Huang, L Li - TrAC Trends in Analytical Chemistry, 2019 - Elsevier
Protein glycosylation plays a key role in various biological processes and disease-related
pathological progression. Mass spectrometry (MS)-based glycoproteomics is a powerful …

N-GlycositeAtlas: a database resource for mass spectrometry-based human N-linked glycoprotein and glycosylation site map**

S Sun, Y Hu, M Ao, P Shah, J Chen, W Yang, X Jia… - Clinical proteomics, 2019 - Springer
Background N-linked glycoprotein is a highly interesting class of proteins for clinical and
biological research. The large-scale characterization of N-linked glycoproteins …

Peptide profiling and the bioactivity character of yogurt in the simulated gastrointestinal digestion

Y **, Y Yu, Y Qi, F Wang, J Yan, H Zou - Journal of Proteomics, 2016 - Elsevier
This study investigated the relationship between peptide profiles and the bioactivity
character of yogurt in simulated gastrointestinal trials. A total of 250, 434 and 466 peptides …

Hydrophilic phytic acid-coated magnetic graphene for titanium (IV) immobilization as a novel hydrophilic interaction liquid chromatography–immobilized metal affinity …

Y Hong, H Zhao, C Pu, Q Zhan, Q Sheng… - Analytical …, 2018 - ACS Publications
In this work, multifunctional Ti4+-immobilized phytic acid-modified magnetic graphene
(denoted as MagG@ PEI@ PA-Ti4+) nanocomposites were fabricated through a facile route …

Facile synthesis of zwitterionic polymer-coated core–shell magnetic nanoparticles for highly specific capture of N-linked glycopeptides

Y Chen, Z **ong, L Zhang, J Zhao, Q Zhang, L Peng… - Nanoscale, 2015 - pubs.rsc.org
Highly selective and efficient capture of glycosylated proteins and peptides from complex
biological samples is of profound significance for the discovery of disease biomarkers in …

Enrichment and separation techniques for large-scale proteomics analysis of the protein post-translational modifications

J Huang, F Wang, M Ye, H Zou - Journal of Chromatography A, 2014 - Elsevier
Comprehensive analysis of the post-translational modifications (PTMs) on proteins at
proteome level is crucial to elucidate the regulatory mechanisms of various biological …

Recent advances in metal-organic frameworks for separation and enrichment in proteomics analysis

Q Liu, N Sun, C Deng - TrAC Trends in Analytical Chemistry, 2019 - Elsevier
Metal-organic frameworks (MOFs) have been broadly applied to sample preparation which
is an essential step in proteomics research. Their large surface area provides abundant …

Heterogeneities of Site-Specific N-Glycosylation in HCC Tumors With Low and High AFP Concentrations

T Zhao, L Jia, J Li, C Ma, J Wu, J Shen, L Dang… - Frontiers in …, 2020 - frontiersin.org
Hepatocellular carcinoma (HCC) is still one of the malignant tumors with high morbidity and
mortality in China and worldwide. Although alpha-fetoprotein (AFP) as well as core …

Fishing the PTM proteome with chemical approaches using functional solid phases

Y Zhang, C Zhang, H Jiang, P Yang, H Lu - Chemical Society Reviews, 2015 - pubs.rsc.org
Post-translational modifications (PTMs) are covalent additions of functional groups to
proteins and are known to play essential roles in biological processes. Covalently attached …