The parabrachial nucleus (PBN) in the dorsal pons responds to bodily threats and transmits
alarm signals to the forebrain. Parabrachial neuron activity is enhanced during chronic pain …

Itch is an uncomfortable feeling that evokes a desire to scratch. This protective reflex can
effectively eliminate parasites that invade the skin. When itchy skin becomes severe or lasts …

Itch is a protective sensation that drives scratching. Although specific cell types have been
proposed to underlie itch, the neural basis for itch remains unclear. Here, we used two …

Mechanical itch, which is defined as an itch sensation caused by innocuous mechanical
force, may warn of the potential risk in the skin. The increased mechanosensitivity in sensory …

The lateral parabrachial nucleus (PBN) is critically involved in neuropathic pain modulation.
However, the cellular and molecular mechanisms underlying this process remain largely …

Many hairy mammals perform rapid oscillations of their body, called wet dog shakes, to
remove water and irritants from their back hairy skin. The somatosensory mechanisms that …

In addition to its role in vision, light also serves non-image-forming visual functions. Despite
clinical evidence suggesting the antipruritic effects of bright light treatment, the circuit …

Mammals perform rapid oscillations of their body-“wet dog shakes”-to remove water and
irritants from their back hairy skin. The somatosensory mechanisms underlying this …

Chronic itch remains a clinically challenging condition with limited therapeutic efficacy,
posing a significant burden on patients' quality of life. Despite its prevalence, the underlying …

The parabrachial nucleus (PBN), located in the dorsolateral pons, is involved in many
important biological functions, such as sensory signaling, feeding, defensive behaviors, fear …