Cells have evolved an arsenal of molecular mechanisms to respond to continuous
alterations in the primary structure of DNA. At the cellular level, DNA damage response …

ABSTRACT DNA replication stress is one of the primary causes of genome instability. In
response to replication stress, cells can employ replication restart mechanisms that rely on …

A major obstacle to studying DNA replication is that it involves asynchronous and highly
delocalized events. A reversible replication barrier overcomes this limitation and allows …

The DNA repair scaffold SLX4 has pivotal roles in cellular processes that maintain genome
stability, most notably homologous recombination. Germline mutations in SLX4 are …

Mutations in TDP2, encoding tyrosyl-DNA phosphodiesterase 2, have been associated with
a syndromal form of autosomal recessive spinocerebellar ataxia, type 23 (SCAR23). This is …

Simple Summary The aim of this review is to highlight recent work performed on the activity
of a class of cancer drugs (PARP inhibitor) in various cell lines, either expressing or not …

DNA replication ensures the complete and accurate duplication of the genome. The
traditional approach to analysing perturbation of DNA replication is to use chemical …

When replication forks encounter DNA lesions that cause polymerase stalling, a checkpoint
pathway is activated. The ATR-dependent intra-S checkpoint pathway mediates detection …

SLX4, disabled in the Fanconi anemia group P, is a scaffolding protein that coordinates the
action of structure-specific endonucleases and other proteins involved in the replication …

Chromothripsis describes the catastrophic shattering of mis-segregated chromosomes
trapped within micronuclei. Although micronuclei accumulate DNA double-strand breaks …