Deafness: from genetic architecture to gene therapy
Progress in deciphering the genetic architecture of human sensorineural hearing
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …
Hear and now: Ongoing clinical trials to prevent drug-induced hearing loss
J Lee, K Fernandez… - Annual Review of …, 2024 - annualreviews.org
Each year over half a million people experience permanent hearing loss caused by
treatment with therapeutic drugs with ototoxic side effects. There is a major unmet clinical …
treatment with therapeutic drugs with ototoxic side effects. There is a major unmet clinical …
Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells
KR Koehler, J Nie, E Longworth-Mills, XP Liu… - Nature …, 2017 - nature.com
The derivation of human inner ear tissue from pluripotent stem cells would enable in vitro
screening of drug candidates for the treatment of hearing and balance dysfunction and may …
screening of drug candidates for the treatment of hearing and balance dysfunction and may …
Organoids: a novel modality in disease modeling
Limitations of monolayer culture conditions have motivated scientists to explore new models
that can recapitulate the architecture and function of human organs more accurately. Recent …
that can recapitulate the architecture and function of human organs more accurately. Recent …
Age-related hearing loss: sensory and neural etiology and their interdependence
Age-related hearing loss (ARHL) is a common, increasing problem for older adults, affecting
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …
Correlation between human nervous system development and acquisition of fetal skills: An overview
Understanding the association between fetal nervous system structure and functioning
should be an important goal in neurodevelopmental sciences, especially when considering …
should be an important goal in neurodevelopmental sciences, especially when considering …
[BOOK][B] Foundations of sensation and perception
G Mather - 2016 - taylorfrancis.com
Do you wonder how movies–sequences of static frames–appear to move, or why 3-D films
look different from traditional movies? Why does ventriloquism work, and why can airliner …
look different from traditional movies? Why does ventriloquism work, and why can airliner …
Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells
In view of the prevalence of sensorineural hearing defects in an ageing population, the
development of protocols to generate cochlear hair cells and their associated sensory …
development of protocols to generate cochlear hair cells and their associated sensory …
Gene therapy for inherited hearing loss: updates and remaining challenges
Hearing loss stands as the most prevalent sensory deficit among humans, posing a
significant global health challenge. Projections indicate that by 2050, approximately 10% of …
significant global health challenge. Projections indicate that by 2050, approximately 10% of …
Recent advances and future challenges in gene therapy for hearing loss
AE Amariutei, JY Jeng… - Royal Society Open …, 2023 - royalsocietypublishing.org
Hearing loss is the most common sensory deficit experienced by humans and represents
one of the largest chronic health conditions worldwide. It is expected that around 10% of the …
one of the largest chronic health conditions worldwide. It is expected that around 10% of the …