Regulation of the mevalonate pathway
JL Goldstein, MS Brown - Nature, 1990 - nature.com
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions,
ranging from cholesterol synthesis to growth control. Several mechanisms for feedback …
ranging from cholesterol synthesis to growth control. Several mechanisms for feedback …
Role of Rab GTPases in membrane traffic and cell physiology
AH Hutagalung, PJ Novick - Physiological reviews, 2011 - journals.physiology.org
Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …
[BOOK][B] Guide to yeast genetics and molecular and cell biology, Part C
C Guthrie, GR Fink - 2002 - books.google.com
This volume and its companion, Volume 350, are specifically designed to meet the needs of
graduate students and postdoctoral students as well as researchers, by providing all the up …
graduate students and postdoctoral students as well as researchers, by providing all the up …
Mechanisms of intracellular protein transport
JE Rothman - Nature, 1994 - nature.com
Recent advances have uncovered the general protein apparatus used by all eukaryotes for
intracellular transport, including secretion and endocytosis, and for triggered exocytosis of …
intracellular transport, including secretion and endocytosis, and for triggered exocytosis of …
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
We have investigated the in vivo functional role of rab5, a small GTPase associated with the
plasma membrane and early endosomes. Wild-type rab5 or rab5-ile133, a mutant protein …
plasma membrane and early endosomes. Wild-type rab5 or rab5-ile133, a mutant protein …
rab5 controls early endosome fusion in vitro
The small GTP-binding protein rab5 was previously localized on early endosomes and on
the cytoplasmic face of the plasma membrane. Using a cell-free assay, we have now tested …
the cytoplasmic face of the plasma membrane. Using a cell-free assay, we have now tested …
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments
A set of 11 clones encoding putative GTP binding proteins highly homqlogous to the yeast
YP7Y/SEC4 gene products have been isolated from an MDCK cell cDNA library. We …
YP7Y/SEC4 gene products have been isolated from an MDCK cell cDNA library. We …
Rabs and their effectors: achieving specificity in membrane traffic
BL Grosshans, D Ortiz, P Novick - Proceedings of the …, 2006 - National Acad Sciences
Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the
guanine nucleotide-dependent switch mechanism common to the superfamily to regulate …
guanine nucleotide-dependent switch mechanism common to the superfamily to regulate …
Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.
Small GTPases of the rab family control distinct steps of intracellular transport. The function
of their GTPase activity is not completely understood. To investigate the role of the …
of their GTPase activity is not completely understood. To investigate the role of the …
The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae.
DR TerBush, T Maurice, D Roth, P Novick - The EMBO journal, 1996 - embopress.org
In the yeast Saccharomyces cerevisiae, the products of at least 15 genes are involved
specifically in vesicular transport from the Golgi apparatus to the plasma membrane …
specifically in vesicular transport from the Golgi apparatus to the plasma membrane …