Abstract Systems genetics is an approach to understand the flow of biological information
that underlies complex traits. It uses a range of experimental and statistical methods to …

The molecular biology revolution led to an intense focus on the study of interactions
between DNA, RNA and protein biosynthesis in order to develop a more comprehensive …

Cellular oxidative and electrophilic stress triggers a protective response in mammals
regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to …

Introduction Variation in an individual's response to environmental factors is likely to
influence susceptibility to complex human diseases. The genetic basis of such variation is …

Highlights•SERPINE2 knockdown inhibits radioresistance and DNA damage repair by
mediating RAD51 in lung cancer.•SERPINE2 promotes ATM phosphorylation by directly …

Background Gut microbiota (GMB) alteration has been reported to influence the Alzheimer's
disease (AD) pathogenesis through immune, endocrine, and metabolic pathways. This study …

Tuberculosis (TB) is a major public health problem. One-third of the world's population is
estimated to be infected with Mycobacterium tuberculosis (MTB), the etiological agent …

Background Substantial variations in the prevalence of mild cognitive impairment (MCI)
have been reported, although mostly in Western countries. Less is known about MCI in the …

Testicular cancer represents the most curable solid tumor, with a 10-year survival rate of
more than 95%. Given the young average age at diagnosis, it is estimated that effective …

Genome-wide association studies (GWASs) have shown a large number of genetic variants
to be associated with complex diseases. The identification of the causal variant within an …