Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …

Overweight and obesity are characterized by excessive fat mass accumulation produced
when energy intake exceeds energy expenditure. One plausible way to control energy …

With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Perturbations in lipid homeostasis combined with conditions favoring oxidative stress
constitute a hallmark of the inflammatory response. In this review we focus on the most …

Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases
(NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β …

Succinate, traditionally viewed as a mere intermediate of the tricarboxylic acid (TCA) cycle,
has emerged as a critical mediator in inflammation. Disruptions within the TCA cycle lead to …

Mass spectrometry imaging (MSI) has accelerated our understanding of lipid metabolism
and spatial distribution in tissues and cells. However, few MSI studies have approached lipid …

Ethnopharmacological relevance Licorice is a medicinal herb with a 2000-year history of
applications in traditional Chinese medicine. Isoliquiritigenin (ISL) is a bioactive chalcone …

Systemic, chronic, low-grade inflammation (SCLGI) underlies the pathogenesis of various
widespread diseases. It is often associated with bone loss, thus connecting chronic …

Background and aims Flavonoids are a class of secondary plant metabolites that have been
shown to have multiple health benefits, including antioxidant and anti-inflammatory. This …