Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of
patients with chronic liver disease. Their prevention or reversal have become major …

The overall structure and architecture of the extracellular matrix undergo dramatic alterations
in composition, form, and functionality over time. The stochasticity begins during …

Protein thermodynamics is intimately tied to biological function and can enable processes
such as signal transduction, enzyme catalysis, and molecular recognition. The relative free …

Abstract Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase
and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located …

Vascular smooth muscle cell (vSMC) is highly plastic as its phenotype can change in
response to mechanical cues inherent to the extracellular matrix (ECM). VSMC may be …

Summary Discoidin domain receptor 1 (DDR1) is a tyrosine kinase collagen adhesion
receptor that mediates cell migration through association with non-muscle myosin IIA …

Abstract Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine
kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1. Individuals …

Basement membranes (BMs) are highly specialised extracellular matrix (ECM) structures
that within the heart underlie endothelial cells (ECs) and surround cardiomyocytes and …

The basement membrane (BM) is a specialized layer of extracellular matrix components that
plays a central role in maintaining lung and kidney functions. Although the composition of …

Renal fibrogenesis is the common final pathway to all renal injuries that consequently leads
to Chronic Kidney Disease (CKD). Renal fibrogenesis corresponds to the replacement of …