Enhancing biopolymer hydrogel functionality through interpenetrating networks

AP Dhand, JH Galarraga, JA Burdick - Trends in Biotechnology, 2021 - cell.com
Traditional hydrogels are strong candidates for biomedical applications; however, they may
suffer from drawbacks such as weak mechanics, static properties, and an inability to fully …

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

H Liu, Y Wang, K Cui, Y Guo, X Zhang… - Advanced …, 2019 - Wiley Online Library
Significant advances in materials, microscale technology, and stem cell biology have
enabled the construction of 3D tissues and organs, which will ultimately lead to more …

Standardizing designed and emergent quantitative features in microphysiological systems

DM Nahon, R Moerkens, H Aydogmus… - Nature biomedical …, 2024 - nature.com
Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …

From arteries to capillaries: approaches to engineering human vasculature

S Fleischer, DN Tavakol… - Advanced functional …, 2020 - Wiley Online Library
From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple
scales and cell types. The convergence of bioengineering, materials science, and stem cell …

Advances in microfluidic blood–brain barrier (BBB) models

A Oddo, B Peng, Z Tong, Y Wei, WY Tong… - Trends in …, 2019 - cell.com
Therapeutic options for neurological disorders currently remain limited. The intrinsic
complexity of the brain architecture prevents potential therapeutics from reaching their …

Microfluidic tissue engineering and bio‐actuation

M Filippi, T Buchner, O Yasa, S Weirich… - Advanced …, 2022 - Wiley Online Library
Bio‐hybrid technologies aim to replicate the unique capabilities of biological systems that
could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic …

[HTML][HTML] Cardiovascular disease models: a game changing paradigm in drug discovery and screening

H Savoji, MH Mohammadi, N Rafatian, MK Toroghi… - Biomaterials, 2019 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Organ‐on‐a‐chip for cancer and immune organs modeling

W Sun, Z Luo, J Lee, HJ Kim, KJ Lee… - Advanced …, 2019 - Wiley Online Library
Bridging the gap between findings in preclinical 2D cell culture models and in vivo tissue
cultures has been challenging; the simple microenvironment of 2D monolayer culture …

Engineering of hydrogel materials with perfusable microchannels for building vascularized tissues

R **e, W Zheng, L Guan, Y Ai, Q Liang - Small, 2020 - Wiley Online Library
Vascular systems are responsible for various physiological and pathological processes
related to all organs in vivo, and the survival of engineered tissues for enough nutrient …

Coaxial cell printing of freestanding, perfusable, and functional in vitro vascular models for recapitulation of native vascular endothelium pathophysiology

G Gao, JY Park, BS Kim, J Jang… - Advanced healthcare …, 2018 - Wiley Online Library
Abstract 3D printing technology is used to produce channels within hydrogels followed by
endothelial cells (ECs)‐seeding to establish in vitro vascular models. However, as built‐in …