Toll-like receptor (TLR)-7 is an endosomal innate immune sensor capable of detecting
single-stranded ribonucleic acid. TLR7-mediated induction of type I interferon and other …

One of the most powerful and multifaceted cytokines produced by immune cells are type I
interferons (IFNs), the basal secretion of which contributes to the maintenance of immune …

Understanding the molecular pathways driving the acute antiviral and inflammatory
response to SARS‐CoV‐2 infection is critical for develo** treatments for severe COVID …

Plasmacytoid dendritic cells (pDCs) are specialized cells of the immune system that are
thought to be the main cellular source of type I interferon alpha (IFNα) in response to viral …

Local immunomodulation can be a promising strategy to augment the efficacy and decrease
off-target toxicities associated with cancer treatment. Pancreatic cancer is resistant to …

Plasmacytoid dendritic cells (pDCs) are the major producers of type I interferons (IFNs),
which are essential to mount antiviral and antitumoral immune responses. To avoid …

Objective The interferon (IFN) type I signature is present in over half of patients with primary
Sjögren's syndrome (pSS) and associated with higher disease-activity and autoantibody …

NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …

Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great
potential to produce large amounts of type I interferon (IFN). pDC are involved in the …

Mitochondrial reactive oxygen species (mtROS) generated continuously under physiological
conditions have recently emerged as critical players in the regulation of immune signaling …