Background Studies to detect associations between DNA markers and traits of interest in
humans and livestock benefit from increasing the number of individuals genotyped …

Motivation: Information about haplotype structures gives a more detailed picture of genetic
variation between individuals than single-locus analyses. Databases that contain the most …

In genetic association studies, haplotype data provide more refined information than data
about separate genetic markers. However, large-scale studies that genotype hundreds to …

We assume that allele frequency data have been extracted from several large DNA pools,
each containing genetic material of up to hundreds of sampled individuals. Our goal is to …

Background Typically, the first phase of a genome wide association study (GWAS) includes
genoty** across hundreds of individuals and validation of the most significant SNPs …

Haplotype information could lead to more powerful tests of genetic association than single‐
locus analyses but it is not easy to estimate haplotype frequencies from genotype data due …

Background Pooling is a cost effective way to collect data for genetic association studies,
particularly for rare genetic variants. It is of interest to estimate the haplotype frequencies …

Computationally inferring the identities and their relative frequencies from pooled samples
that are whole-genome or segmentally genotyped or sequenced (eg, using next-generation …

In this dissertation, we present a novel method--the Learning with Iteration and Tree-based
Search Estimation algorithm--for the estimation of the malarial haplotype composition in one …