AMPK is a highly conserved master regulator of metabolism, which restores energy balance
during metabolic stress both at the cellular and physiological levels. The identification of …

Mitochondria participate in crucial cellular processes such as energy harvesting and
intermediate metabolism. Although mitochondria possess their own genome—a vestige of …

Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is
important for very low-density lipoprotein (VLDL) production and thus energy distribution to …

Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

Epithelial-to-mesenchymal transition (EMT) determines the most lethal features of cancer,
metastasis formation and chemoresistance, and therefore represents an attractive target in …

Plants produce and accumulate triacylglycerol (TAG) in their seeds as an energy reservoir to
support the processes of seed germination and seedling development. Plant seed oils are …

Through epigenetic mechanisms cells integrate environmental stimuli to fine-tune gene
expression levels. Mitochondrial function is essential to provide the intermediate metabolites …

Skeletal and cardiac muscles play key roles in the regulation of systemic energy
homeostasis and display remarkable plasticity in their metabolic responses to caloric …

Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …

Nutrient sensing and damage sensing are two fundamental processes in living organisms.
While hyperglycemia is frequently linked to diabetes-related vulnerability to microbial …