Introduction Process map** (PM) supports better understanding of complex systems and
adaptation of improvement interventions to their local context. However, there is little …

This companion article to Sox and Greenfield's report describes better research methods for
CER. It addresses the fundamental limitations of traditional randomized, controlled trials for …

Ethical and Scientific Implications of the Globalization of Clinical Research Page 1 sounding
board The new england journal of medicine n engl j med 360;8 nejm.org february 19, 2009 …

The hypothesis that ablative therapies (such as surgery or radiation) can be used to cure
patients with a limited number of metastases was influential in changing practice. Early …

I am incredibly fortunate. To receive an award from the Lasker Foundation, with its
preeminent jury, is indeed an honor. But the greatest reward is seeing patients every week …

Purpose: Postactivation barriers to oncology clinical trial accruals are well documented;
however, potential barriers prior to trial opening are not. We investigate one such barrier …

Background A major challenge for randomized phase III oncology trials is the frequent low
rates of patient enrollment, resulting in high rates of premature closure due to insufficient …

Cancer is the leading cause of death in Americans younger than 85 years of age and kills
one American every 56 seconds. Advances in understanding of cancer biology have given …

Background: Palliative medicine has made rapid progress in establishing its scientific and
clinical legitimacy, yet the evidence base to support clinical practice remains deficient in …

Objective: To investigate predictors of trial start-up times, high attrition, and poor protocol
adherence in amyotrophic lateral sclerosis (ALS) trials. Methods: Retrospective analysis of …