Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance
ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …
and mechanistically distinct substrates against steep concentration gradients. Among the …
Human efflux transport of testosterone, epitestosterone and other androgen glucuronides
E Järvinen, H Kidron, M Finel - The Journal of Steroid Biochemistry and …, 2020 - Elsevier
Several drug-metabolizing enzymes are known to control androgen homeostasis in humans.
UDP-glucuronosyltransferases convert androgens to glucuronide conjugates in the liver and …
UDP-glucuronosyltransferases convert androgens to glucuronide conjugates in the liver and …
Efflux and uptake transport and gut microbial reactivation of raloxifene glucuronides
A Uoti, M Kurkela, M Niemi, T Oksanen… - Basic & Clinical …, 2025 - Wiley Online Library
Raloxifene has low bioavailability due to extensive glucuronidation in the intestine and the
liver, and its pharmacokinetics is associated with high intra‐and interindividual variability …
liver, and its pharmacokinetics is associated with high intra‐and interindividual variability …
Application of the metal ions as potential population biomarkers for wastewater-based epidemiology: estimating tobacco consumption in Southern China
L Xu, Y Lu, D Wu, X Li, M Song, T Hang… - … Geochemistry and Health, 2023 - Springer
Wastewater-based epidemiology (WBE) is an objective approach for the estimation of
population-level exposure to a wide range of substances, in which the use of a population …
population-level exposure to a wide range of substances, in which the use of a population …
Biotransformation of carbamazepine and nicotine in juvenile American alligator (Alligator mississippiensis) in vitro hepatic S9 vs. in situ perfused liver
American alligators (Alligator mississippiensis) are apex predators and sentinel species in
the coastal wetland ecosystem along the Gulf of Mexico. There is concern for alligator …
the coastal wetland ecosystem along the Gulf of Mexico. There is concern for alligator …
The Effects of Drugs of Abuse on ABC Transporters
ATP-binding cassette (ABC) transporters are a superfamily of integral membrane proteins
located in several places in the human body, including the blood-brain barrier (BBB), and …
located in several places in the human body, including the blood-brain barrier (BBB), and …