Obstructive sleep apnea, obesity hypoventilation syndrome, and pulmonary hypertension: a state-of-the-art review

S Bjork, D Jain, MH Marliere, SA Predescu… - Sleep Medicine …, 2024 - sleep.theclinics.com
Pulmonary hypertension (PH) is a heterogeneous disorder with varying outcomes across
different PH groups. The prevalence of sleep-disordered breathing (SDB) and obstructive …

[HTML][HTML] Air pollution and the airways: lessons from a century of human urbanization

J Goossens, AC Jonckheere, LJ Dupont, DMA Bullens - Atmosphere, 2021 - mdpi.com
Since the industrial revolution, air pollution has become a major problem causing several
health problems involving the airways as well as the cardiovascular, reproductive, or …

Impact of socioeconomic status on cancer incidence and stage at diagnosis: selected findings from the surveillance, epidemiology, and end results: National …

LX Clegg, ME Reichman, BA Miller, BF Hankey… - Cancer causes & …, 2009 - Springer
Background Population-based cancer registry data from the Surveillance, Epidemiology,
and End Results (SEER) Program at the National Cancer Institute (NCI) are mainly based on …

[HTML][HTML] Rapamycin improves satellite cells' autophagy and muscle regeneration during hypercapnia

J Balnis, EL Jackson, LA Drake, DV Singer… - JCI …, 2025 - pmc.ncbi.nlm.nih.gov
Both CO2 retention, or hypercapnia, and skeletal muscle dysfunction predict higher mortality
in critically ill patients. Mechanistically, muscle injury and reduced myogenesis contribute to …

Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation …

DE Phelan, M Shigemura, S Aldhafiri, C Mota… - Frontiers in …, 2021 - frontiersin.org
The nuclear receptor sub-family 4 group A (NR4A) family are early response genes that
encode proteins that are activated in several tissues/cells in response to a variety of …

Carbon dioxide-dependent signal transduction in mammalian systems

DE Phelan, C Mota, C Lai, SJ Kierans… - Interface …, 2021 - royalsocietypublishing.org
Carbon dioxide (CO2) is a fundamental physiological gas known to profoundly influence the
behaviour and health of millions of species within the plant and animal kingdoms in …

Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells

LA Dada, LC Welch, ND Magnani, Z Ren, H Han… - JCI …, 2023 - pmc.ncbi.nlm.nih.gov
Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are
among the most common symptoms in patients with COVID-19 after hospital discharge. In …

Comparing effects of breathing exercises alone and combined with breathing-stretching exercises on respiratory indices, disease severity and exercise capacity in …

F Zare, M Karimyar Jahromi, Z Rahmanian… - Scientific Reports, 2025 - nature.com
No study has ever comprehensively investigated the effect of rehabilitation exercises on
patients with chronic obstructive pulmonary disease, taking into account different aspects …

Hypercapnia in the critically ill: insights from the bench to the bedside

C Masterson, S Horie, SD McCarthy… - Interface …, 2021 - royalsocietypublishing.org
Carbon dioxide (CO2) has long been considered, at best, a waste by-product of metabolism,
and at worst, a toxic molecule with serious health consequences if physiological …

Elevated CO2 Levels Delay Skeletal Muscle Repair by Increasing Fatty Acid Oxidation

E Ceco, D Celli, S Weinberg, M Shigemura… - Frontiers in …, 2021 - frontiersin.org
Muscle dysfunction often occurs in patients with chronic obstructive pulmonary diseases
(COPD) and affects ventilatory and non-ventilatory skeletal muscles. We have previously …