Recurrent driver mutations in benign tumors

CC Gomes - Mutation Research/Reviews in Mutation Research, 2022 - Elsevier
The understanding of the molecular pathogenesis of benign tumors may bring essential
information to clarify the process of tumorigenesis, and ultimately improve the understanding …

Somatic whole genome dynamics of precancer in Barrett's esophagus reveals features associated with disease progression

TG Paulson, PC Galipeau, KM Oman… - Nature …, 2022 - nature.com
While the genomes of normal tissues undergo dynamic changes over time, little is
understood about the temporal-spatial dynamics of genomes in premalignant tissues that …

[HTML][HTML] Clonal expansion of cancer driver gene mutants investigated using advanced sequencing technologies

BL Parsons - Mutation Research-Reviews in Mutation Research, 2024 - Elsevier
Advanced sequencing technologies (ASTs) have revolutionized the quantitation of cancer
driver mutations (CDMs) as rare events, which has utility in clinical oncology, cancer …

[HTML][HTML] The differences between fecal microbiota and intestinal fluid microbiota in colon polyps: An observational study

X Zhou, S Zhang, D Liu, H Qian, D Zhang, Q Liu - Medicine, 2021 - journals.lww.com
The differences between fecal microbiota and intestinal flui... : Medicine The differences
between fecal microbiota and intestinal fluid microbiota in colon polyps: An observational …

Forward and reverse mutations in stages of cancer development

T Hu, Y Kumar, I Shazia, SJ Duan, Y Li, L Chen… - Human genomics, 2018 - Springer
Background Massive occurrences of interstitial loss of heterozygosity (LOH) likely resulting
from gene conversions were found by us in different cancers as a type of single-nucleotide …

Within‐patient phylogenetic reconstruction reveals early events in Barrett's Esophagus

LP Smith, JA Yamato, PC Galipeau… - Evolutionary …, 2021 - Wiley Online Library
Barrett's Esophagus is a neoplastic condition which progresses to esophageal
adenocarcinoma in 5% of cases. Key events affecting the outcome likely occur before …

Approaching cancer evolution from different angles

FD Ciccarelli, J DeGregori - Iscience, 2020 - cell.com
Dr. Francesca Ciccarelli (The Francis Crick Institute, UK) and Dr. James DeGregori
(University of Colorado, USA) interview three top scientists in clinical (Dr. Charles Swanton …

Somatic whole genome dynamics of precancer in Barrett's esophagus

T Paulson, P Galipeau, K Oman, C Sanchez, M Kuhner… - 2021 - researchsquare.com
While the genomes of normal tissues undergo dynamic changes over time, little is
understood about the temporal-spatial dynamics of genomes in premalignant tissues that …

High Molecular-Weight Hyaluronan Prevents Basal Cell Carcinoma Via Promoting Apoptosis In Cancer-Initiating Adult Stem Cells

V Liu - 2019 - search.proquest.com
Basal cell carcinoma (BCC), a keratinocyte cancer, is the most common human neoplasm
worldwide. Although rarely metastatic, BCC is associated with high morbidity rates with …

Forward-reverse mutation cycles between stages of cancer development

T Hu, Y Kumar, I Shazia, SJ Duan, Y Li, L Chen… - bioRxiv, 2017 - biorxiv.org
Earlier, prominent occurrences of interstitial loss-of-heterozygosities (LOHs) were found in
different cancers as a type of single-nucleotide-variations (SNVs), at rates far exceeding …