Bone morphogenetic protein-2 (BMP-2) is currently the only Food and Drug Administration
(FDA)-approved osteoinductive growth factor used as a bone graft substitute. However, with …

Stem cells are cells specialized cell, capable of renewing themselves through cell division
and can differentiate into multi-lineage cells. These cells are categorized as embryonic stem …

Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …

Mesenchymal stromal cells (MSCs) are promising candidates for tissue engineering and
regenerative medicine. The multipotent stem cell component of MSC isolates is able to …

Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …

The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …

Stem cell fate is influenced by specialized microenvironments that remain poorly defined in
mammals,,. To explore the possibility that haematopoietic stem cells derive regulatory …

Haematopoietic stem cells (HSCs) are a subset of bone marrow cells that are capable of self-
renewal and of forming all types of blood cells (multi-potential). However, the HSC 'niche' …

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

The TGF-β family comprises many structurally related differentiation factors that act through
a heteromeric receptor complex at the cell surface and an intracellular signal transducing …